Contribution of adipogenesis to healthy adipose tissue expansion in obesity
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View abstract on PubMed
Summary
This summary is machine-generated.The ability to create new fat cells (adipogenesis) is key to healthy white adipose tissue expansion in obesity. This process influences metabolic health and may offer strategies to combat obesity-related diseases.
Area Of Science
- Metabolic Health
- Obesity Research
- Adipose Tissue Biology
Background
- White adipose tissue (WAT) expansion and remodeling influence metabolic syndrome risk.
- Visceral WAT accumulation increases insulin resistance risk, while subcutaneous WAT expansion is protective.
- Pathologic WAT remodeling (hypertrophy, inflammation, fibrosis) correlates with insulin resistance.
Purpose Of The Study
- To review human and rodent studies on adipose tissue expansion and remodeling in obesity.
- To highlight the role of adipogenesis in healthy WAT expansion.
- To discuss advances in understanding adipose stem cell populations and their role in adipogenesis.
Main Methods
- Review of recent human and rodent studies.
- Analysis of single-cell RNA sequencing data.
- Discussion of adipose stem cell biology and adipogenesis.
Main Results
- Adipogenesis is critical for healthy WAT distribution and remodeling in obesity.
- Metabolically healthy obese individuals exhibit smaller, more numerous adipocytes with less inflammation and fibrosis.
- Single-cell RNA sequencing aids in identifying tissue-resident progenitor populations in WAT.
Conclusions
- Adipogenesis is a key determinant of healthy adipose tissue expansion and remodeling.
- Understanding adipose stem cell biology can lead to strategies to prevent metabolic disease in obesity.
- Targeting adipogenesis may decouple obesity from metabolic dysfunction.
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