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Updated: Jan 6, 2026
07:16
Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
Published on: September 13, 2018
20.6K
Special Issue on "Disease and the Hippo Pathway"
1University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh bioQuarter, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. Carsten.G.Hansen@ed.ac.uk.
Cells
|October 3, 2019
Summary
The Hippo pathway regulates organ size and development. Its dysregulation is linked to cancer, making it a key target for new therapies.
Area of Science:
- Cell Biology
- Developmental Biology
- Molecular Biology
Background:
- The Hippo pathway is a crucial regulator of organ size, controlling cell proliferation and apoptosis.
- It plays vital roles in embryonic development and tissue homeostasis throughout life.
Discussion:
- Dysregulation of the Hippo pathway is implicated in various cancers, affecting tumor growth and metastasis.
- Understanding Hippo pathway signaling is essential for developing targeted cancer therapies.
Key Insights:
- The Hippo pathway integrates mechanical and extracellular signals to control gene expression.
- Key components include MST1/2 kinases, LATS1/2 kinases, and their downstream effectors YAP/TAZ.
Outlook:
- Further research into Hippo pathway modulators could lead to novel therapeutic strategies.
- Investigating the pathway's role in regenerative medicine holds significant promise.
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