Related Experiment Video

Updated: Jan 6, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor
07:16

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor LATS Biosensor

Published on: September 13, 2018

20.6K

Special Issue on "Disease and the Hippo Pathway"

Carsten Gram Hansen1,2

  • 1University of Edinburgh Centre for Inflammation Research, Queen's Medical Research Institute, Edinburgh bioQuarter, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. Carsten.G.Hansen@ed.ac.uk.

Cells
|October 3, 2019
PubMed

Insights

The Hippo pathway regulates organ size and development. Its dysregulation is linked to cancer, making it a key target for new therapies.

Area of Science:

  • Cell Biology
  • Developmental Biology
  • Molecular Biology

Background:

  • The Hippo pathway is a crucial regulator of organ size, controlling cell proliferation and apoptosis.
  • It plays vital roles in embryonic development and tissue homeostasis throughout life.

Discussion:

  • Dysregulation of the Hippo pathway is implicated in various cancers, affecting tumor growth and metastasis.
  • Understanding Hippo pathway signaling is essential for developing targeted cancer therapies.

Key Insights:

  • The Hippo pathway integrates mechanical and extracellular signals to control gene expression.
  • Key components include MST1/2 kinases, LATS1/2 kinases, and their downstream effectors YAP/TAZ.

Outlook:

  • Further research into Hippo pathway modulators could lead to novel therapeutic strategies.
  • Investigating the pathway's role in regenerative medicine holds significant promise.

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