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Breakthroughs in medicine and bioimaging with up-conversion nanoparticles
Iman Rostami1,2, Hamideh Rezvani Alanagh2, Zhiyuan Hu2,3
1Laboratory of Biomolecular Research, Department of Biology and Chemistry, Paul Scherrer Institute, Villigen, PSI 5232, Switzerland.
International Journal of Nanomedicine
|October 3, 2019
Summary
Lanthanide-doped up-conversion nanoparticles (UCNPs) offer advanced nanomedicine solutions for disease diagnosis and treatment. Their unique properties enable precise multimodal bioimaging and drug delivery for challenging conditions.
Area of Science:
- Biochemistry
- Materials Chemistry
- Nanomedicine
Background:
- Nanomedicine leverages nanoscale materials for advanced diagnostics and therapeutics.
- Lanthanide-doped up-conversion nanoparticles (UCNPs) are inorganic nanoparticles with significant biomedical potential.
Purpose of the Study:
- To review the fundamental physical and optical properties of UCNPs.
- To illustrate the applications of UCNPs in bioimaging, theranostics, cancer therapy, and optogenetics.
Main Methods:
- Fundamental understanding of UCNP physical and optical properties.
- Review of UCNP applications in various biomedical fields.
Main Results:
- UCNPs exhibit excellent potential for multimodal bioimaging (fluorescence and electron microscopy).
- UCNPs facilitate efficient drug and biomaterial transport for targeted therapies.
- UCNPs show promise in theranostics, cancer therapy, and optogenetics.
Conclusions:
- UCNPs are versatile agents in nanomedicine due to their unique optical properties and drug-carrying capabilities.
- Further exploration of UCNPs can lead to novel diagnostic and therapeutic strategies for difficult-to-cure diseases.
