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Updated: Jan 6, 2026

The Lambda Select cII Mutation Detection System
Published on: April 26, 2018
The remarkable UV light invulnerability of thymine GNA dinucleotides
Stéphanie Coantic-Castex1, Agathe Martinez2, Dominique Harakat2
1Université de Reims Champagne Ardenne, Institut de Chimie Moléculaire de Reims, CNRS UMR 7312, UFR de Pharmacie, 51 rue Cognacq-Jay, F-51096 Reims Cedex, France. pascale.clivio@univ-reims.fr.
Abstract:
We herein demonstrate the UV resistance of glycol nucleic acid (GNA) dinucleotides. This resistance sustains the hypothesis of GNA as a nucleic acid prebiotic ancestor on early Earth, a time of intense solar UV light. Such photorobustness, due to the absence of intrastrand base stacking, could offer an opportunity for nanodevice development requiring challenging UV conditions.
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