Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Decrease in hypothalamic epinephrine concentration and other neurochemical changes produced by quinpirole, a dopamine

R W Fuller, S K Hemrick-Luecke

    Journal of Neural Transmission
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Persistence of long-lasting serotonin depletion by p-chloroamphetamine in rat brain after 6-hydroxydopamine lesioning of dopamine neurons.

    Biochemical pharmacology·1995
    Same author

    Assessing equivalence of inhaled drugs.

    Respiratory medicine·1995
    Same author

    Postoperative radiation therapy in clinical stage I endometrial cancer: corpus, cervical, and lower uterine segment involvement--patterns of failure.

    Radiology·1995
    Same author

    The effect of topical fluticasone propionate on intranasal histamine challenge in subjects with perennial allergic rhinitis.

    Clinical otolaryngology and allied sciences·1995
    Same author

    Systemic effects of glucocorticoids--a response.

    British journal of clinical pharmacology·1995
    Same author

    Are there any detrimental effects of the use of inhaled long-acting beta 2-agonists in the treatment of asthma?

    Chest·1995

    Quinpirole, a D2 dopamine receptor agonist, reduces hypothalamic epinephrine and alters dopamine and norepinephrine metabolites in rats. These effects, mediated by D2 receptor activation, highlight quinpirole's impact on central catecholamine systems.

    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • Quinpirole is a selective D2 dopamine receptor agonist.
    • Dopamine receptor agonists influence various neurochemical pathways.

    Purpose of the Study:

    • To investigate the neurochemical effects of quinpirole in the rat brain.
    • To determine the role of D2 receptor activation in quinpirole's actions.

    Main Methods:

    • Administration of quinpirole to rats.
    • Measurement of neurotransmitter and metabolite concentrations in brain regions (hypothalamus, cerebral hemispheres, brain stem).
    • Use of dopamine antagonists (spiperone) and selective D1 agonists (SKF 38393) for mechanistic studies.

    Main Results:

    • Quinpirole (≥0.3 mg/kg) decreased hypothalamic epinephrine.

    Related Experiment Videos

  • Higher doses (2-3 mg/kg) increased hypothalamic dopamine and decreased norepinephrine, while increasing MHPG sulfate in the brain stem and hypothalamus.
  • Effects were blocked by spiperone and not mimicked by a D1 agonist or inactive quinpirole enantiomer.

    • Conclusions:

    • Quinpirole's neurochemical effects are mediated by D2 receptor activation.
    • Quinpirole decreases dopamine metabolites and hypothalamic epinephrine.
    • Quinpirole enhances norepinephrine turnover, likely via increased release, indicated by elevated MHPG sulfate.