Stability of dynamic functional architecture differs between brain networks and states
Le Li1, Bin Lu2, Chao-Gan Yan3
1CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing, China.
Neuroimage
|October 3, 2019
Summary
Brain functional connectivity stability varies by region. High-order association areas are stable at rest, while sensory regions show less stability and decrease during visual tasks.
Area of Science:
- Neuroscience
- Cognitive Science
- Brain Imaging
Background:
- Neural connectivity is dynamic, yet its temporal stability is crucial for brain function.
- Characterizing the stability of brain functional architecture over time has been overlooked.
Purpose of the Study:
- To quantify the temporal stability of functional architecture in the brain at a ~1-minute timescale.
- To compare stability between association and unimodal brain regions.
- To investigate how natural viewing (movie watching) alters functional stability in children and adolescents.
Main Methods:
- Measured dynamic functional connectivity (DFC) concordance over time for each brain voxel.
- Utilized resting-state fMRI data from adults for reliability testing.
- Analyzed fMRI data from children and adolescents during movie watching and rest.
Main Results:
- High-order association regions, including the default mode network, exhibited high resting-state stability.
- Primary sensory-motor cortices showed lower stability compared to association regions.
- Movie watching decreased stability in the primary visual cortex, correlating with increased DFC variation.
- Higher-order visual stream regions demonstrated increased stability during movie watching.
Conclusions:
- The brain's functional stability profile differs between high-order association and primary sensory areas.
- Visual stimuli dynamically alter functional stability in specific brain regions.
- Understanding functional stability may aid in studying distinct mental states and neurological disorders.
Keywords:
Association regionDynamic functional connectivityFunctional stabilityMovie watchingResting stateMore Related Videos
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