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Updated: Jan 6, 2026
28:13
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
33.8K
The left atrial appendage in humans: structure, physiology, and pathogenesis
Nabeela Karim1, Siew Yen Ho1, Edward Nicol1
1Department of Cardiology, The Royal Brompton and Harefield NHS Foundation Trust, Imperial College London, Sydney Street, London, UK.
Summary
The left atrial appendage (LAA) is a vital heart organ, not a remnant. Dysfunction increases stroke risk, while LAA ablation can treat atrial fibrillation.
Area of Science:
- Cardiology
- Cardiac Anatomy
- Electrophysiology
Background:
- The left atrial appendage (LAA) was historically viewed as an embryological remnant.
- Emerging evidence highlights the LAA as a complex, functional cardiac organ.
- LAA dysfunction is linked to thrombogenesis and cardioembolic events.
Purpose of the Study:
- To provide an in-depth review of the LAA's structure, physiology, and pathophysiology.
- To explore the LAA's role in cardiac haemodynamics and volume homeostasis.
- To discuss LAA interventions and their outcomes.
Main Methods:
- Comprehensive literature review of LAA structure, function, and pathology.
- Analysis of LAA's contribution to haemodynamics and neurohormonal secretion.
- Examination of LAA's role in atrial fibrillation and therapeutic interventions.
Main Results:
- The LAA actively influences cardiac haemodynamics and volume regulation.
- LAA dysfunction is a significant factor in thrombogenesis and cardioembolic risk.
- LAA ablation shows promise for electrical isolation and maintaining sinus rhythm.
Conclusions:
- The LAA is a critical organ with significant clinical implications.
- Targeting the LAA offers therapeutic potential for reducing thrombotic and arrhythmic events.
- Further understanding of LAA pathophysiology is crucial for optimizing interventions.
Keywords:
AnatomyAtrial fibrilationLeft atrial appendageLeft atrial appendage electrical isolationLeft atrial appendage occlusionPhysiologyStrokeThrombogenesisMore Related Videos
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