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Aberrant Thyroid Function Tests in a Patient Taking Biotin Supplements.

Zara Latif¹, Marc J Crupie²

¹Internal Medicine, University of Tennessee Health Science Center, Memphis, USA.

|October 4, 2019

Summary

Biotin supplements can interfere with thyroid function tests (TFTs), potentially leading to misdiagnosis of hyperthyroidism. Careful monitoring is advised for patients taking biotin to ensure accurate thyroid assessment.

Keywords:

biotin biotin-streptavidin immunoassay thyroid thyroid autoimmunity thyroid dysfunction thyrotoxicosis

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Area of Science:

Endocrinology
Nutritional Biochemistry

Background:

Biotin, a B-complex vitamin, is prevalent in over-the-counter supplements.
Recent reports indicate biotin's interference with thyroid function tests (TFTs).

Observation:

A case study involved a patient presenting with hyperthyroid TFTs and a positive radioactive iodine uptake (RAIU) scan.
The patient was concurrently taking biotin supplements.

Findings:

Thyroid function tests normalized approximately one month after biotin cessation.
TFTs remained normal even after the patient resumed biotin supplementation.

Implications:

Interpreting TFTs in patients using biotin supplements presents a diagnostic challenge.
Suggests increased monitoring for patients on biotin before initiating anti-thyroid treatments.