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Updated: Jan 6, 2026

04:53
An In Vitro Approach to Photodynamic Therapy
Published on: August 17, 2018
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Mitochondrial heat shock protein-guided photodynamic therapy
Ajesh P Thomas1, An-Jung Lee2, L Palanikumar1
1Department of Chemistry, School of Natural Sciences, Ulsan National Institute of Science and Technology (UNIST), Ulsan-44919, South Korea.
Abstract:
Mitochondria targeting sensitizers are continuing to gain importance in photodynamic therapy (PDT). Members of the 90 kDa heat shock protein (Hsp90) family, including TRAP1 (Hsp75), are overexpressed in cancer cells and help to control the antiapoptotic protein activity. The present work introduces an Hsp90 inhibitor-mitochondria targeting indocyanine dye conjugate (IR-PU) for high PDT efficacy.

