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A water soluble light activated hydrogen sulfide donor induced by an excited state meta effect
Manoranjan Bera1, Somnath Maji2, Amrita Paul1
1Department of Chemistry, Indian Institute of Technology Kharagpur, 721302 Kharagpur, West Bengal, India. ndpradeep@chem.iitkgp.ernet.in.
Abstract:
We have utilized an m-amino benzyl based photoremovable protecting group (PRPG) to develop a new water soluble H2S donor. It efficiently releases H2S on demand in a spatio-temporally controlled fashion by an excited state "meta effect" with good chemical and photochemical quantum yield in an aqueous environment. The efficient photorelease of H2S under physiological conditions was also demonstrated by in vitro studies.
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