The NCATS Pharmaceutical Collection: a 10-year update.

Area of Science:

• Pharmacology
• Drug Discovery
• Translational Science

Background:

• The National Center for Advancing Translational Sciences (NCATS) Pharmaceutical Collection (NPC) was established as a public resource in 2011.
• It comprises a comprehensive set of clinically approved drugs.

Purpose of the Study:

• To provide an update on the NCATS Pharmaceutical Collection (NPC).
• To review the successes and lessons learned from a decade of NPC data generation and utilization.
• To report on efforts to update the NPC with recently approved drugs.

Main Methods:

• Systematic profiling of NPC compounds across diverse biological pathways and disease models.
• Data analysis to identify drug repurposing opportunities and biological insights.
• Integration of newly approved drugs into the collection.

Main Results:

• Generation of a substantial dataset from systematic drug profiling.
• Identification of novel drug repurposing candidates, some currently in clinical trials.
• Uncovering new biological insights into drug targets and disease mechanisms.
• Updating the NPC with drugs approved in recent years.

Conclusions:

• The NPC has proven invaluable for drug repurposing and advancing biological understanding.
• Ongoing efforts ensure the NPC remains a current and comprehensive resource.
• The NPC continues to facilitate translational science and drug discovery.