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Going green with solar-powered ILC3 homeostasis
1Department of Immunology, University of Toronto, Toronto, ON M5S 1A8, Canada.
Science Immunology
|October 6, 2019
Summary
Circadian clock proteins, BMAL1 and REV-ERBα, regulate the development and function of group 3 innate lymphoid cells (ILC3). This research highlights the crucial role of the circadian system in immune cell biology.
Area of Science:
- Immunology
- Chronobiology
- Cell Biology
Background:
- Innate lymphoid cells (ILCs) are critical immune cells involved in host defense and tissue homeostasis.
- The circadian clock regulates numerous physiological processes, but its role in ILC development and function is not fully understood.
Purpose of the Study:
- To investigate the role of circadian clock proteins BMAL1 and REV-ERBα in the development and function of group 3 innate lymphoid cells (ILC3).
Main Methods:
- Analysis of ILC3 development and function in genetically modified mouse models with altered expression of BMAL1 and REV-ERBα.
- Flow cytometry and gene expression analysis were used to assess ILC3 populations and their functional characteristics.
Main Results:
- BMAL1 and REV-ERBα were found to be key regulators of ILC3 development.
- These circadian clock proteins influence the functional capacity of ILC3, impacting their cytokine production and tissue-homing potential.
Conclusions:
- The circadian clock, through proteins BMAL1 and REV-ERBα, plays a harmonizing role in the development and function of ILC3.
- These findings reveal a novel link between circadian rhythms and innate immunity, suggesting potential therapeutic targets for immune-related disorders.
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