Cardiotoxicity of Immune Therapy
Sarju Ganatra1, Rohan Parikh2, Tomas G Neilan3
1Cardio-Oncology Program, Division of Cardiovascular Medicine, Department of Medicine, Lahey Hospital and Medical Center, 41 Mall road, Burlington, MA 01805, USA; Cardio-Oncology and Adult Cancer Survivorship Program, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
Cardiology Clinics
|October 8, 2019
Summary
Immunotherapy offers new cancer treatments but can cause serious heart problems. Cardiologists play a key role in managing immunotherapy-related cardiotoxicity for better patient outcomes.
Area of Science:
- Oncology
- Cardiology
- Immunotherapy
Background:
- Immunotherapy, including immune checkpoint inhibitors and CAR T-cell therapy, has transformed cancer treatment for many malignancies.
- These advanced therapies, while effective, are linked to significant and potentially fatal cardiovascular adverse events.
- The expanding use of immunotherapy necessitates a focus on managing its cardiac side effects.
Purpose of the Study:
- To review the cardiotoxicity associated with modern immunotherapies.
- To discuss current and potential management strategies for immunotherapy-induced cardiotoxicity.
- To highlight the essential role of cardiologists in managing these complex cases.
Main Methods:
- Literature review of contemporary immunotherapy agents.
- Analysis of reported cardiovascular adverse events.
- Synthesis of current management guidelines and emerging strategies.
Main Results:
- Cardiotoxicity is a serious concern with immunotherapies like checkpoint inhibitors and CAR T-cells.
- Various cardiovascular manifestations can occur, requiring prompt recognition.
- Management strategies are evolving, emphasizing multidisciplinary care.
Conclusions:
- Cardiovascular adverse effects are a critical consideration in immunotherapy.
- Early detection and intervention are crucial for managing cardiotoxicity.
- Cardiologists are integral to the comprehensive care of patients receiving immunotherapy.
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