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Updated: Jan 6, 2026

Real-Time Metabolic Detection in Living Cells Using Hyperpolarized 13C NMR
Published on: July 8, 2025
Relayed hyperpolarization from para-hydrogen improves the NMR detectability of alcohols
Peter J Rayner1, Ben J Tickner1, Wissam Iali1
1Centre for Hyperpolarisation in Magnetic Resonance , Department of Chemistry , University of York , Heslington , YO10 5DD , UK .
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The detection of alcohols by magnetic resonance techniques is important for their characterization and the monitoring of chemical change. Hyperpolarization processes can make previously inpractical measurements, such as the determination of low concentration intermediates, possible. Here, we investigate the SABRE-Relay method in order to define its key characteristics and improve the resulting 1H NMR signal gains which subsequently approach 103 per proton. We identify optimal amine proton transfer agents for SABRE-Relay and show how catalyst structure influences the outcome. The breadth of the method is revealed by expansion to more complex alcohols and the polarization of heteronuclei.
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