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Published on: December 10, 2020
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Biomaterial-Based Metabolic Regulation in Regenerative Engineering.
Chuying Ma1, Michelle L Kuzma1, Xiaochun Bai2,3
1Department of Biomedical Engineering Materials Research Institute The Huck Institutes of the Life Sciences The Pennsylvania State University University Park PA 16802 USA.
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|October 9, 2019
Summary
Material cues can influence cell metabolism, impacting cell behavior in regenerative engineering. Understanding this interplay is key for developing advanced biomaterials that control cellular functions.
Area of Science:
- Biomaterials Science
- Cellular Metabolism
- Regenerative Engineering
Background:
- Cell metabolism critically regulates cell functions like differentiation and immune response in regenerative engineering.
- The influence of material cues on intracellular metabolic pathways remains underexplored, despite known material modulation of cell functions.
Purpose of the Study:
- To provide an overview of how cell metabolism regulation impacts cell function.
- To discuss how material cues influence cell metabolism and subsequent cell behavior.
Main Methods:
- Review of recent evidence on material-biometabolism interactions.
- Analysis of how material properties (chemical, physical, metabolic factors) affect cellular metabolic homeostasis (energy, oxygen, redox).
Main Results:
- Material cues, including released factors, biochemical properties, and physical characteristics, can modulate cell metabolism.
- Specific material cues like ions, metabolites, oxygen, antioxidant properties, adhesivity, composition, topography, and stiffness influence metabolic pathways.
Conclusions:
- Modulating cell metabolism through biomaterials offers a promising strategy for regenerative engineering.
- Further development of biomaterials that regulate cell metabolism will significantly advance regenerative medicine applications.
