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RanGAP1 plays a vital role in anti-infective functions of macrophages and sepsis progression

Linlin Mao1, Genming Liu1, Jiahuan Zhang2

  • 1Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.

Immunology Letters
|April 29, 2026
PubMed

Insights

Ran GTPase-activating protein 1 (RanGAP1) is crucial for macrophage immune response and sepsis survival. Low RanGAP1 expression impairs anti-infective functions, worsening sepsis outcomes.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Ran GTPase-activating protein 1 (RanGAP1) regulates nucleocytoplasmic transport.
  • Its role in innate immunity and sepsis is not well understood.

Purpose of the Study:

  • To investigate the function of RanGAP1 in macrophage immune responses.
  • To determine the association between RanGAP1 expression and sepsis outcomes.

Main Methods:

  • Analysis of RanGAP1 expression in septic patients.
  • In vitro studies using lipopolysaccharide (LPS) stimulation of macrophages.
  • Murine model of sepsis (cecal ligation and puncture - CLP) using RanGAP1-deficient macrophages.

Main Results:

  • Low RanGAP1 expression correlates with poor survival in septic patients.
  • RanGAP1 expression and localization are dynamic in LPS-stimulated macrophages.
  • RanGAP1 deficiency in macrophages exacerbates sepsis progression.
  • RanGAP1 deficiency impairs macrophage anti-infective functions, including cytokine production, pathogen clearance, and antigen processing.

Conclusions:

  • RanGAP1 is a key regulator of macrophage immune responses.
  • RanGAP1 activity is critical for determining sepsis outcomes.
  • Targeting RanGAP1 may offer therapeutic potential for sepsis.
Keywords:
Anti-infectionLipopolysaccharideMacrophageRanGAP1Sepsis

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