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05:26
Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
Published on: March 1, 2024
Clinical Characteristics and Risk Factors for Mortality in Candidemia: A Retrospective Single-Center Study in China
Sihai Zhou1, Xin Zhang2, Kaixuan Yuan3
1Department of Clinical Laboratory, Suzhou Ninth People's Hospital Affiliated to Soochow University, Suzhou, Jiangsu, 215200, People's Republic of China.
Infection and Drug Resistance
|July 6, 2026
Summary
Candidemia, a severe hospital infection, has a high mortality rate. Prolonged antifungal therapy (≥14 days) is the only independent risk factor for 28-day mortality in patients with candidemia.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Clinical Microbiology
Background:
- Candidemia is a significant cause of hospital-acquired infections and mortality.
- Evaluating clinical characteristics and outcomes is crucial for managing this infection.
Purpose of the Study:
- To assess clinical features, species distribution, and antifungal susceptibility in candidemia patients.
- To identify factors influencing 28-day outcomes in candidemia cases.
Main Methods:
- Retrospective analysis of 169 candidemia patients from January 2021 to December 2023.
- Comparison of clinical data, species, time to positivity, and antifungal susceptibility between survivors and non-survivors.
- Multivariable logistic regression to identify independent risk factors for mortality.
Main Results:
- The 28-day mortality rate was 52.07%, with Candida albicans being the most common species.
- Candida tropicalis exhibited high resistance to fluconazole (33.33%) and voriconazole (37.04%).
- Antifungal therapy duration of ≥14 days was the sole independent predictor of 28-day mortality.
Conclusions:
- Candida albicans is the predominant species in candidemia, associated with severe outcomes.
- Vigilant monitoring of resistance patterns and risk factors is essential for effective candidemia management.
- Extended antifungal therapy (≥14 days) is critical for improving patient survival in candidemia.
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