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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
[Children born too soon and outcomes]
Ulrika Ådén1, Karin Sävman2, Mikael Norman3
1Karolinska Institutet - Stockholm, Sweden - , Sweden.
Insights
Extremely preterm infants require ongoing monitoring for lung function and neurodevelopment as they enter school. Early detection of developmental issues is crucial for supporting these children.
Area of Science:
- Neonatal Medicine
- Pediatric Pulmonology
- Developmental Pediatrics
Background:
- Advances in perinatal care increase survival rates for extremely preterm infants (born before 28 weeks gestation).
- These survivors face significant risks for long-term disabilities, with increased adverse development at lower gestational ages.
- Lung function and neurodevelopmental outcomes are common concerns for extremely preterm children.
Purpose of the Study:
- To highlight the long-term needs of extremely preterm children entering school.
- To emphasize the importance of continued monitoring of lung function and neurodevelopment.
- To inform educational and healthcare strategies for this vulnerable population.
Main Methods:
- This study is a review of current understanding and clinical practice regarding extremely preterm infants.
- It synthesizes data on developmental outcomes, focusing on lung function and neurodevelopment.
- The review considers the transition from neonatal intensive care to school age.
Main Results:
- While most preterm infants develop normally, extremely preterm infants have a higher risk of long-term disabilities.
- Obstructive lung symptoms are frequent, necessitating treatment.
- Cognitive and neuropsychiatric issues are increasingly recognized, alongside major neuromotor impairments like cerebral palsy.
Conclusions:
- Extremely preterm children require comprehensive follow-up of lung function and neurodevelopment until school entry.
- Early identification and intervention are essential to address the specific needs of these children in educational settings.
- Continued research and clinical attention are vital for optimizing outcomes for extremely preterm survivors.
Abstract:
Advances in perinatal intensive care have resulted in increased survival of the most immature preterm infants (born before 28 gestational weeks) and these new survivors are now entering school. While the clear majority of all children born preterm have a normal development, the extremely preterm infant is at a considerable risk for long term disabilities and rates of adverse development increase at lower gestational ages. Lung function is commonly affected in children born extremely preterm, and many have treatment for obstructive symptoms. The incidences of major neuromotor impairments, i.e. cerebral palsy, are low, but there is an increasing awareness of common cognitive and neuropsychiatric problems in extremely preterm children and their special needs in school. Extremely preterm children therefore need follow up of lung function and neurodevelopment at least until school start.
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