Design and rationale of the North Indian ST-Segment Elevation Myocardial Infarction Registry: A prospective cohort

Sameer Arora1,2, Arman Qamar3, Puneet Gupta4

  • 1Division of Cardiology, University of North Carolina, Chapel Hill, North Carolina.

Clinical Cardiology
|October 9, 2019
PubMed

Insights

This study examines ST-segment elevation myocardial infarction (STEMI) care in North India, focusing on underserved populations. Findings aim to improve treatment strategies and patient outcomes for heart attacks in the region.

Area of Science:

  • Cardiology
  • Public Health
  • Epidemiology

Background:

  • ST-segment elevation myocardial infarction (STEMI) poses significant mortality and morbidity risks globally.
  • Limited contemporary data exists on STEMI care processes and outcomes in India, particularly for underserved populations.
  • Tertiary medical centers in New Delhi serve a large, socioeconomically disadvantaged patient group from various Indian states lacking specialized cardiovascular care.

Purpose of the Study:

  • To establish the North Indian ST-segment elevation myocardial infarction (NORIN STEMI) registry.
  • To gain insights into contemporary risk factor profiles, treatment practices, and prognosis for STEMI patients in an underserved North Indian population.
  • To identify opportunities for enhancing STEMI care outcomes in India.

Main Methods:

  • Prospective cohort study design.
  • Data collection from government-funded, low-cost tertiary medical centers in New Delhi, India.
  • Institutional Review Board approval and informed consent obtained from all participants.

Main Results:

  • The NORIN STEMI registry provides crucial data on STEMI management in a specific Indian demographic.
  • Analysis of risk factors, treatment patterns, and patient prognosis is ongoing.
  • Results will highlight challenges and successes in managing STEMI within resource-limited settings.

Conclusions:

  • The NORIN STEMI registry is vital for understanding STEMI care in underserved North Indian populations.
  • Findings are expected to inform evidence-based strategies for improving STEMI management and patient outcomes across India.
  • This research addresses a critical gap in cardiovascular care data for a vulnerable patient group.

Related Concept Videos

Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
186
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
683
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
321
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
2.7K
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
426
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
837