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Oculo-skeletal dysplasia in five Labrador Retrievers
Lionel Sebbag1, Alexandra Riggs2, Joyce Carnevale1
1Department of Veterinary Clinical Sciences, Iowa State University, College of Veterinary Medicine, Ames, Iowa.
Veterinary Ophthalmology
|October 10, 2019
Summary
Oculo-skeletal dysplasia (OSD) in Labrador Retrievers causes vision deficits and skeletal abnormalities. Genetic testing is crucial for diagnosis and breed health, with yearly monitoring recommended for cataracts and osteoarthritis.
Area of Science:
- Veterinary Genetics
- Canine Ophthalmology
- Canine Orthopedics
Background:
- Oculo-skeletal dysplasia (OSD) is a genetic disorder affecting Labrador Retrievers.
- Understanding the clinical manifestations of OSD is essential for accurate diagnosis and management.
Observation:
- This study reviewed five Labrador Retrievers diagnosed with OSD between 2008 and 2018.
- Clinical data included physical and ophthalmic examinations, ocular ultrasound, electroretinogram, and radiographic imaging.
Findings:
- All affected dogs were homozygous for the OSD mutation.
- Common physical abnormalities included vision deficits, dwarfism, carpal valgus, and alopecia.
- Ophthalmic findings comprised cataracts, vitreous syneresis, and retinal separation. Radiographic changes revealed shortened ulna, curved radius, elbow incongruity, hip dysplasia, and osteoarthritis.
- Progression of cataracts and osteoarthritis was noted in follow-up cases.
Implications:
- Genetic testing is critical for diagnosing OSD and preventing its transmission in Labrador Retrievers.
- Regular monitoring for cataracts and osteoarthritis is recommended for affected dogs.
- Early diagnosis and management can improve the quality of life for dogs with OSD.
