Related Experiment Video
Updated: Jan 6, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
Update on long QT syndrome
Víctor Neira1, Andrés Enriquez1, Chris Simpson1
1Division of Cardiology, Queen's University, Kingston, Ontario, Canada.
Abstract:
Long QT syndrome (LQTS) is an inherited disorder characterized by a prolonged QT interval in the 12-lead electrocardiogram and increased risk of malignant arrhythmias in patients with a structurally normal heart. Since its first description in the 1950s, advances in molecular genetics have greatly improved our understanding of the cause and mechanisms of this disease. Sixteen genes linked to LQTS have been described and genetic testing had become an integral part of the diagnosis and risk stratification. This article provides an updated review of the genetic basis, diagnosis, and clinical management of LQTS.
More Related Videos
Related Concept Videos
Pleiotropy
Dysrhythmias III: Characteristics of Dysrhythmias
Quartile
1; 1; 2; 2; 4; 6; 6.8; 7.2; 8; 8.3; 9; 10; 10; 11.5
The median or second quartile is seven. The lower half of the...
Cardiomyopathy III: Hypertrophic Cardiomyopathy
Dysrhythmias IV: Characteristics of Bradyarrhythmias
Detection of Gross Error: The Q Test

