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Updated: Jan 6, 2026

3D Imaging of Soft-Tissue Samples using an X-ray Specific Staining Method and Nanoscopic Computed Tomography
Published on: October 24, 2019
Analysis of Soft Tissue Materials for Simulation Development
Julia Caldwell1, James J Mooney
1From Emory University, Children's Healthcare of Atlanta (J.J.M.), Atlanta, GA; and Vitality Pain of Bowling Green (J.C.), Bowling Green, KY.
Researchers explored casting materials like silicone, urethane, foams, and gels to create realistic soft tissue simulants for medical training. Silicone and urethane show promise for both imaging and interventions.
Area of Science:
- Biomedical Engineering
- Materials Science
- Medical Simulation
Background:
- Custom medical training simulations are often cost-effective alternatives to purchased models.
- Existing 3D printing materials have physical limitations for soft tissue simulation.
- This study investigates materials for creating realistic soft tissue simulants.
Purpose of the Study:
- To evaluate physical properties of castable materials for soft tissue simulant creation.
- To assess suitability of materials for medical imaging and interventions.
- To explore cost-effective simulant production.
Main Methods:
- Casting various materials (foams, rubbers, urethanes, silicones, gels) into standardized forms.
- Visualizing samples using computed tomography (CT) and ultrasound (US).
- Measuring needle penetration force (18ga and 22ga needles).
Main Results:
- Silicone rubbers visualized well with US; CT showed 100-200 Hounsfield units (HU).
- Gels had low HU (-175 to 8) and were US-clear; foams (urethanes) had low HU and were US-opaque.
- Needle forces ranged from 0.05-23.34 N; gels/foams were lower, with silicone overlap. Additives altered silicone properties.
Conclusions:
- Silicone and urethane materials effectively mimic soft tissues for imaging and interventions.
- Potential exists for producing custom, high-fidelity simulants independently.
- Further research needed to optimize material combinations and techniques.
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