P₂O₅-Free Cerium Containing Glasses: Bioactivity and Cytocompatibility Evaluation.

Area of Science:

• Biomaterials Science
• Materials Chemistry
• Biotechnology

Background:

• Investigating P2O5-free bioactive glasses doped with cerium (CeO2).
• Utilizing Kokubo (K) composition as a base for glass preparation.
• Evaluating glasses with varying CeO2 concentrations (1.2, 3.6, 5.3 mol%).

Purpose of the Study:

• To assess the bioactivity and cytocompatibility of novel P2O5-free, CeO2-doped glasses.
• To understand the effect of cerium doping on glass properties and biological interactions.
• To explore the potential of these glasses as advanced biomaterials.

Main Methods:

• Glasses prepared via a melting method.
• Bioactivity tested in simulated body fluid (SBF); cytotoxicity assessed using MLO-Y4 cell lines.
• Ion leaching analyzed by ICP-MS and ICP-OES; surface characterized by SEM and XRD.

Main Results:

• P2O5-free cerium-doped glasses meet European bioactivity standards.
• Cerium enhances glass durability and influences hydroxyapatite (HA) formation.
• Increased cerium content correlates with improved cell proliferation, particularly for K5.3.

Conclusions:

• P2O5-free cerium-doped bioactive glasses represent a promising new class of biomaterials.
• The enhanced bioactivity and cytocompatibility support their use in biomedical applications.
• Cerium doping offers a tunable approach to developing advanced bioactive glass formulations.