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Dietary Compounds for Targeting Prostate Cancer

Seungjin Noh1, Eunseok Choi2, Cho-Hyun Hwang3

  • 1College of Korean Medicine, Kyung Hee University, Seoul 02453, Korea. nohapril@khu.ac.kr.

Nutrients
|October 11, 2019
PubMed

Insights

Dietary compounds show promise in fighting prostate cancer by inducing apoptosis and other mechanisms. These natural substances offer potential as both food supplements and clinical drugs.

Area of Science:

  • Oncology
  • Nutritional Science
  • Pharmacology

Background:

  • Prostate cancer is a significant global health concern, ranking as the third most common cancer worldwide.
  • Current chemotherapy treatments for prostate cancer face challenges due to side effects, necessitating exploration of alternative therapies.

Purpose of the Study:

  • To evaluate the efficacy of dietary substances as potential anti-tumor agents against prostate cancer.
  • To identify specific anti-cancer mechanisms of action for various dietary compounds.

Main Methods:

  • Literature review and analysis of existing studies on dietary substances and their effects on prostate cancer.
  • Identification of carcinostatic activities through mechanisms including apoptosis, anti-angiogenesis, anti-metastasis, microRNA regulation, and overcoming multi-drug resistance (MDR).

Main Results:

  • Approximately seventy dietary substances demonstrated anti-prostate cancer activity.
  • A majority of these substances were found to induce apoptosis, notably through caspase and poly adenosine diphosphate ribose polymerase (PARP) cleavage.

Conclusions:

  • Dietary compounds exhibit significant potential as therapeutic agents for prostate cancer.
  • These findings support the use of dietary substances as both complementary food supplements and direct clinical drugs for cancer treatment.
Keywords:
MiRNAangiogenesisapoptosisdietary compoundsmetastasismulti drug resistancenatural compoundsprostate cancer

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