Related Experiment Video
Updated: Jul 18, 2026
11:18
Expanding Cytotoxic T Lymphocytes from Umbilical Cord Blood that Target Cytomegalovirus, Epstein-Barr Virus, and Adenovirus
Published on: May 7, 2012
A human T cell lymphoma secreting an immunoglobulin E specific helper factor
The Journal of Clinical Investigation
|June 1, 1985
Summary
This study found that a T cell lymphoma in a child with non-Hodgkin's lymphoma produced elevated immunoglobulin E (IgE). The lymphoma cells exhibited IgE-specific helper function, suggesting a link between T cell lymphomas and aberrant IgE production.
Area of Science:
- Immunology
- Oncology
- Cell Biology
Background:
- Non-Hodgkin's lymphoma can present with extremely high serum immunoglobulin E (IgE) levels, even in non-allergic individuals.
- The underlying mechanisms connecting T cell lymphomas and elevated IgE are not fully understood.
Observation:
- An 8-year-old girl with non-Hodgkin's lymphoma exhibited hyper-IgE ( >10,000 IU/ml) without allergies or parasitic infection.
- Serum IgE levels normalized with chemotherapy-induced remission and rose again upon lymphoma recurrence.
- Lymphoma cells expressed T3+, T4+, and T8+ markers and possessed Fc receptors for IgE.
Findings:
- Lymphoma cell supernatants significantly enhanced IgE production in B cells from allergic patients but not normal subjects.
- The lymphoma cells demonstrated IgE-specific helper function, indicating a role in modulating IgE synthesis.
- Isoelectric focusing showed the elevated IgE was polyclonal, suggesting a systemic response rather than solely tumor production.
Implications:
- This T cell lymphoma may represent a clonal expansion of IgE-specific helper T cells.
- Understanding this interaction could offer new insights into T cell-mediated immune dysregulation in lymphoma.
- Further research may explore therapeutic strategies targeting this specific T cell subset.
More Related Videos
Related Concept Videos
01:22T Cell Activation and Clonal Selection
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
01:24T Cell Types and Functions
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...