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Modulation of immune function by UV radiation.

M L Kripke, W L Morison

    The Journal of Investigative Dermatology
    |July 1, 1985
    PubMed
    Summary
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    Ultraviolet (UV) radiation impacts the immune system, causing local and distant effects. UV exposure can suppress immune responses, potentially contributing to skin cancer and other skin diseases.

    Area of Science:

    • Immunology
    • Dermatology
    • Photobiology

    Background:

    • Ultraviolet (UV) radiation possesses carcinogenic properties and influences immune reactions.
    • UV-induced immunologic alterations manifest as both local and distant effects.
    • Understanding these effects is crucial for skin cancer and cutaneous disease pathogenesis.

    Purpose of the Study:

    • To investigate the local and distant immunologic alterations induced by UV radiation in mice.
    • To differentiate between types of distant immunologic alterations caused by UV exposure.
    • To explore the mechanisms underlying UV-induced immune modulation.

    Main Methods:

    • Exposure of mouse skin to UV radiation.
    • Assessment of local immune reactions at the irradiation site.

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  • Evaluation of immune reactions at distant, non-irradiated sites.

    • Main Results:

    • UV radiation induced local immunologic alterations at the site of exposure.
    • Two types of distant immunologic alterations were identified: nonspecific and antigen-specific.
    • Nonspecific alterations involved leukocyte accumulation and suppressed delayed hypersensitivity and local graft-versus-host (GVH) reactions.
    • Antigen-specific alterations resulted from DNA damage, involved soluble mediators, and suppressed contact hypersensitivity, leading to suppressor T lymphocyte formation.

    Conclusions:

    • UV radiation significantly modulates immune responses both locally and systemically.
    • Distant immunologic effects of UV radiation are distinct and mechanistically different.
    • These UV-induced immune changes may play a role in the development of skin cancer and other skin conditions.