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Acute effects of different doses of malathion on the rat liver
Çınar Severcan1, Murat Ekremoglu2, Bayram Sen3
1Department of Biochemistry, Faculty of Pharmacy, Zonguldak Bulent Ecevit University, Turkey.
Aim Of The Study:
Our study was designed to evaluate the acute effects of malathion on rat liver tissues.
Material And Methods:
The animals were divided into 4 groups of 6 animals/each. Group 1 (control group) received corn oil, while groups 2, 3, and 4 were given malathion dissolved in corn oil at a dose of 100, 200 and 400 mg/kg, respectively. 24 hours after malathion administration, animals were sacrificed and liver tissues were collected. The liver tissues were then analysed biochemically and histopathologically.
Results:
Butyrylcholinesterase levels in groups 2, 3 and 4 were significantly lower than that of group 1. Total oxidant status and tumour necrosis factor alpha level were significantly increased in group 4 compared to group 1. Catalase activities of groups 3 and 4 were significantly higher than that of group 1. Arylesterase activity was significantly decreased in groups 3 and 4 compared to group 1. In groups 3 and 4, some vacuoles in hepatocytes were revealed and hydropic degeneration was observed in group 4.
Conclusions:
Acute administrations of malathion results in hepatotoxicity in a dose-dependent manner.
