Related Experiment Video
Updated: Jan 6, 2026
10:10
A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
19.4K
Tuberculosis in Systemic Lupus Erythematosus Patients.
M F Ahmmed1, M N Islam, S Ferdous
1Dr Md Faysal Ahmmed, Consultant, BRB Hospital, Dhaka, Bangladesh.
Mymensingh Medical Journal : MMJ
|October 11, 2019
Summary
Tuberculosis (TB) significantly impacts patients with Systemic Lupus Erythematosus (SLE), with 10% of patients in this study developing TB. High SLE disease activity and cumulative steroid use were identified as key risk factors for TB development.
Area of Science:
- Rheumatology
- Infectious Diseases
- Public Health
Background:
- Tuberculosis (TB) is a major cause of illness and death in Systemic Lupus Erythematosus (SLE) patients globally.
- Developing countries face a significant and persistent challenge with TB in SLE populations.
Purpose of the Study:
- To determine the frequency of tuberculosis in SLE patients.
- To identify risk factors associated with tuberculosis development in SLE patients.
Main Methods:
- An observational study involving 230 SLE patients was conducted in Bangladesh.
- Data collected included clinical characteristics, TB history, SLEDAI scores, and immunosuppressant doses.
- Diagnostic methods for TB included tuberculin tests, chest X-rays, AFB sputum analysis, Gene Xpert, ADA, FNAC, and tissue biopsy.
Main Results:
- Tuberculosis was diagnosed in 23 (10%) of the 230 SLE patients.
- Pulmonary TB occurred in 15 patients, and extra-pulmonary TB in 8 patients.
- Significant risk factors for TB included high SLE disease activity (SLEDAI score >12) and cumulative prednisolone intake >1000mg.
Conclusions:
- The frequency of tuberculosis in SLE patients is notably high (10%).
- Managing SLE disease activity and judicious steroid use are crucial for TB prevention.
- Increased awareness and preventive strategies are recommended to reduce TB incidence in SLE patients.
Related Concept Videos
01:29Pulmonary Tuberculosis I
796
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
796
01:26Pulmonary Tuberculosis IV
459
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
459
01:31Pulmonary Tuberculosis III
872
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
872
01:28Pulmonary Tuberculosis II
1.3K
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
1.3K
01:28Pulmonary Tuberculosis V
516
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
516
01:17Other Pulmonary Disorders
1.4K
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
1.4K