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Autoluminescence-Free Prostate-Specific Antigen Detection by Persistent Luminous Nanorods and Au@Ag@SiO2
Yuan Zhao1, Fangjie Zheng1, Lixia Shi1
1Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, International Joint Research Center for Photoresponsive Molecules and Materials, School of Chemical and Material Engineering , Jiangnan University , Wuxi 214122 , China.
Abstract:
The sensitive detection of biomarker with high selectivity and accuracy is of remarkable significance for the early screening and clinical diagnosis of malignant cancer. Persistent phosphors play a role in illumination-free biosensing owing to their unparalleled optical properties, which produces long-lasting luminescence without the illumination to eliminate the interference of autofluorescence and scattering light from biological matrix. In this study, ZnGeO:Mo persistent luminescence nanorods (PLNRs) were prepared and showed tunable luminescence intensity and decay patterns. An excitation-free luminescent aptasensor was proposed for the detection of prostate specific antigen (PSA) by using ZnGeO:Mo PLNRs as probes and Au@Ag@SiO2 nanoparticles as quenchers. Under optimal conditions, the limit of detection for PSA was 9.2 pg mL-1. This work creates a possibility for the preparation of multiplex colored persistent luminescence nanomaterials with desired decay patterns for multiple bioassay and time-resolved fluoroimmunoassay.
