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Related Experiment Videos

[Hypophosphoremia during mechanical ventilation for chronic obstructive bronchopathies].

P Squara, G Bleichner, M Aubier

    Presse Medicale (Paris, France : 1983)
    |June 1, 1985
    PubMed
    Summary

    Mechanical ventilation can cause hypophosphatemia (low phosphorus) in patients with respiratory failure. Phosphorus levels typically normalize after extubation, suggesting a link to intracellular shifts.

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    Scientific reports·2017

    Area of Science:

    • Critical Care Medicine
    • Pulmonary Medicine
    • Clinical Chemistry

    Context:

    • Hypophosphatemia is a potential complication in patients with chronic obstructive pulmonary diseases (COPD).
    • It can impair respiratory function through muscular mechanisms.
    • Acute respiratory failure necessitating mechanical ventilation is a common scenario in COPD patients.

    Purpose:

    • To investigate the incidence and severity of hypophosphatemia in patients with acute respiratory failure on mechanical ventilation.
    • To explore the relationship between hypophosphatemia, ventilation duration, and phosphorus levels.
    • To examine the association between hypophosphatemia and physiological changes like pH and phosphaturia.

    Summary:

    • In 36 patients with acute respiratory failure requiring mechanical ventilation, initial serum phosphorus levels were normal but decreased significantly within 24 hours of ventilation initiation.

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  • Severe hypophosphatemia ( < 0.30 mmol/l) was observed in four patients after 24 hours.
  • Phosphorus levels gradually increased with enteral nutrition and returned to normal approximately 36 hours post-extubation.
  • The study found a strong correlation between hypophosphatemia and pH improvement, along with a decrease in phosphaturia, suggesting intracellular phosphorus uptake.

    • Impact:

    • Highlights the risk of rapid hypophosphatemia development during mechanical ventilation in respiratory failure patients.
    • Suggests that monitoring phosphorus levels is crucial in this patient population.
    • Provides insights into the physiological mechanisms of phosphorus shifts during mechanical ventilation and recovery.