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Related Experiment Videos

Systematically applied chemicals that damage lung tissue.

J P Kehrer, S Kacew

    Toxicology
    |June 28, 1985
    PubMed
    Summary
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    Report by the editors.

    Toxicology letters·2003

    Many systemic drugs and chemicals can harm lung tissue. This review details known lung toxins, their mechanisms of action, and remaining questions about pulmonary toxicity.

    Area of Science:

    • Toxicology
    • Pulmonary Medicine
    • Biochemistry

    Background:

    • Systemic administration of drugs and chemicals can lead to lung toxicity.
    • Specific mechanisms of pulmonary damage are increasingly understood, involving factors like agent concentration and bioactivation.
    • However, fundamental biochemical lesions and cellular responses to most lung toxins remain poorly defined.

    Purpose of the Study:

    • To review available information on pulmonary biochemical and pathological changes caused by systemic lung toxins.
    • To discuss proposed mechanisms underlying lung damage induced by these agents.
    • To highlight knowledge gaps regarding the susceptibility and responses to lung toxins.

    Main Methods:

    • Literature review of systemic agents causing pulmonary toxicity.

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  • Analysis of biochemical and pathological changes associated with lung toxins.
  • Discussion of proposed mechanisms of lung injury.

    • Main Results:

    • Identified numerous agents causing lung toxicity, including paraquat, thioureas, furans, antineoplastics, and metals.
    • Described mechanisms such as high lung concentration, impaired detoxification, and bioactivation.
    • Highlighted species, age, and cellular differences in susceptibility and response.

    Conclusions:

    • Significant progress has been made in understanding lung toxins, but many questions remain unanswered.
    • Further research is needed to define biochemical lesions, cellular responses, and repair processes.
    • A comprehensive understanding of systemic chemical lung toxicity is crucial for prevention and treatment.