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A novel Mn-Cu bimetallic complex for enhanced chemodynamic therapy with simultaneous glutathione depletion

Shuhua Cao1, Jiangli Fan2, Wen Sun2

  • 1College of Chemistry, Chemical and Environmental Engineering, Weifang University, No. 5147 Dongfeng Street, Weifang, 261061, China. shuhua@wfu.edu.cn and State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2 Linggong Road, Dalian 116024, P. R. China. sunwen@dlut.edu.cn.

Chemical Communications (Cambridge, England)
|October 12, 2019
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Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
Several distinctive characteristics distinguish glutathione conjugation from other phase II...
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