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Related Concept Videos

M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

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Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Mitosis and Cytokinesis01:35

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In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
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Mitosis and Cytokinesis02:03

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In eukaryotes, the cell division cycle is divided into distinct, coordinated cellular processes that include cell growth, DNA replication/chromosome duplication, chromosome distribution to daughter cells, and finally, cell division. The cell cycle is tightly regulated by its regulatory systems as well as extracellular signals that affect cell proliferation.
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Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
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Related Experiment Video

Updated: Jan 5, 2026

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
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Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

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Triggering mitosis.

Adrijana Crncec1, Helfrid Hochegger1

  • 1Genome Damage and Stability Centre, University of Sussex, Brighton, UK.

FEBS Letters
|October 12, 2019
PubMed
Summary

The cell division switch, regulated by cyclin-dependent kinase 1 (Cdk1) activation, is complex. This review explores its systems biology, focusing on timing, robustness, and cancer cell adaptations.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Systems Biology

Background:

  • Mitosis initiation is a critical cell cycle event, primarily regulated by cyclin-dependent kinase 1 (Cdk1) activation.
  • While Cdk1 activation is the core trigger, the underlying regulatory network involves complex signaling cascades with poorly understood system dynamics.

Purpose of the Study:

  • To review the literature on the Cdk1 activation network.
  • To address key systems biology questions regarding the precise control, robustness, and timing of mitotic entry.
  • To explore how this regulatory system adapts to replication stress in cancer cells.

Main Methods:

  • Literature review of Cdk1 activation networks.
  • Analysis of systems biology principles governing cell cycle control.
Keywords:
Cdc25Cdk1GreatwallWee1cell cyclemitosis

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  • Examination of regulatory mechanisms ensuring precise and robust mitotic entry.

    • Main Results:

    • Detailed knowledge exists for many components of the Cdk1 network.
    • Significant gaps remain in understanding how these components integrate for precise and robust mitotic timing.
    • Replication stress in cancer cells may necessitate adaptations in the mitotic entry pathway.

    Conclusions:

    • The regulation of Cdk1 activation is a complex system crucial for accurate cell division.
    • Further systems biology approaches are needed to fully elucidate the control mechanisms and robustness of mitotic entry.
    • Understanding adaptations in cancer cells could reveal novel therapeutic targets.