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Reno-protective effect of berberine

Nawar Raad Hussien1, Hayder M Al-Kuraishy1, Ali Ismail Al-Gareeb1

  • 1Department of Clinical Pharmacology, Medicine and Therapeutic, Al- Mustansiriya University, Baghdad, Iraq.

JPMA. the Journal of the Pakistan Medical Association
|October 12, 2019
PubMed

Insights

Berberine effectively protected against diclofenac-induced acute kidney injury in rats. It reduced kidney damage markers and enhanced antioxidant capacity, showing reno-protective potential.

Area of Science:

  • Pharmacology
  • Toxicology
  • Nephrology

Background:

  • Diclofenac, a non-steroidal anti-inflammatory drug, can cause acute kidney injury.
  • Oxidative stress and inflammation are key mechanisms in drug-induced nephrotoxicity.
  • Berberine is a natural compound with known antioxidant and anti-inflammatory properties.

Purpose of the Study:

  • To investigate the renoprotective effects of berberine against diclofenac-induced acute kidney injury in a rat model.
  • To evaluate the impact of berberine on oxidative stress and inflammatory biomarkers in the kidneys.

Main Methods:

  • Male Sprague Dawley rats were divided into three groups: control, diclofenac-induced injury, and berberine plus diclofenac treatment.
  • Kidney function markers (blood urea, serum creatinine), oxidative stress markers (malondialdehyde, superoxide dismutase, glutathione reductase), and kidney injury biomarkers (NGAL, KIM-1, IL-18, cystatin-c) were measured.
  • Statistical analysis was performed using SPSS 20.

Main Results:

  • Berberine significantly reduced levels of blood urea, serum creatinine, malondialdehyde, NGAL, KIM-1, and IL-18 compared to the diclofenac-only group.
  • Berberine treatment led to a significant increase in superoxide dismutase and glutathione reductase levels, indicating improved antioxidant capacity.
  • The study demonstrated berberine's ability to attenuate kidney damage markers.

Conclusions:

  • Berberine exhibits significant renoprotective effects against diclofenac-induced acute kidney injury in rats.
  • Berberine acts by modulating pro-inflammatory and oxidative stress biomarkers.
  • These findings suggest berberine as a potential therapeutic agent for mitigating NSAID-induced nephrotoxicity.
Abstract

Keywords:
Acute kidney injuryBerberineDiclofenac

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