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Updated: Jan 5, 2026
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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
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A Young Female With Refractory Hypertension
Nima Nassiri1, Marissa Maas1, Eric J Fichtenbaum1
1Institute of Urology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Urology
|October 12, 2019
Summary
A renin-secreting renal tumor (reninoma) caused secondary erythrocytosis and severe hypertension in a young woman. Surgical removal of the tumor normalized hormone levels and blood pressure, resolving the condition.
Area of Science:
- Nephrology
- Endocrinology
- Oncology
Background:
- Secondary erythrocytosis and refractory hypertension can indicate underlying endocrine disorders.
- Elevated aldosterone and renin levels suggest a renin-producing tumor.
- Renal masses require thorough investigation, especially when associated with hormonal imbalances.
Observation:
- A 29-year-old female presented with incidental renal mass, erythrocytosis, and severe hypertension unresponsive to treatment.
- Elevated serum aldosterone and renin levels were detected during diagnostic workup.
Findings:
- Computed tomography revealed a 3 cm left renal mass.
- Pathological examination confirmed a juxtaglomerular cell tumor (reninoma) secreting renin.
Implications:
- Partial nephrectomy led to normalization of aldosterone and renin levels.
- The patient was successfully weaned off antihypertensive medications, resolving her hypertension.
- Reninomas should be considered in the differential diagnosis of secondary erythrocytosis and difficult-to-control hypertension.
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