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Calibration of arterial spin labeling data-potential pitfalls in post-processing.

Joana Pinto¹, Michael A Chappell^2,3, Thomas W Okell²

¹Institute for Systems and Robotics and Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.

Magnetic Resonance in Medicine

|October 13, 2019

Summary

Choosing the right post-processing calibration for arterial spin labeling (ASL) is crucial for accurate perfusion quantification. Careful selection of calibration options minimizes errors and improves the reliability of ASL imaging results.

Keywords:

ASL MRI calibration cerebral blood flow kinetic modeling

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Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling

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Area of Science:

Neuroimaging
Medical Physics
Biomedical Engineering

Background:

Arterial spin labeling (ASL) offers absolute perfusion quantification.
Standardized ASL calibration procedures are lacking, impacting accuracy.
Post-processing calibration significantly influences ASL perfusion results.

Purpose of the Study:

To evaluate the impact of various post-processing calibration options on ASL perfusion quantification and reproducibility.
To compare different ASL calibration methods and post-processing choices.
To assess the influence of calibration on pulsed ASL and pseudo-continuous ASL sequences.

Main Methods:

Systematic comparison of main ASL calibration methods.
Evaluation of various post-processing calibration options.
Analysis of two datasets from common ASL sequences (pASL, pcASL).

Main Results:

Discrepancies in perfusion quantification varied with post-processing calibration options.
Voxelwise and white matter reference tissue methods showed less sensitivity to post-processing than CSF methods.
White matter reference tissue calibration yielded poorer reproducibility and may be unsuitable for white matter pathology.

Conclusions:

Inconsistent post-processing calibration can cause significant errors in ASL perfusion quantification.
A detailed description of the calibration procedure is essential for ASL studies.
The voxelwise calibration method is recommended for its simplicity and intrinsic correction of coil sensitivity profiles.