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Related Experiment Videos

Midazolam oral self-administration.

J L Falk, M Tang

    Drug and Alcohol Dependence
    |May 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Schedule-induced polydipsia revealed midazolam

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Behavioral Science

    Background:

    • Schedule-induced polydipsia is a behavioral phenomenon.
    • Benzodiazepines, like midazolam, are commonly prescribed medications.

    Purpose of the Study:

    • To assess the addiction liability of midazolam using schedule-induced polydipsia.
    • To investigate the physical dependence potential of midazolam.

    Main Methods:

    • Rats were exposed to schedule-induced polydipsia with either water or midazolam solution.
    • Probe sessions with varying fixed-time (FT) schedules were used to assess fluid intake.
    • Choice tests between water and midazolam were conducted.
    • Benzodiazepine antagonists and midazolam were administered to assess their effects on intake.

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  • Physical dependence was evaluated using an auditory stimulus.

    • Main Results:

    • Midazolam intake increased at FT values greater than 1-min compared to water.
    • Rats showed a preference for midazolam over water only at FT 0 and FT 5-min.
    • Benzodiazepine antagonists did not affect fluid intake.
    • Midazolam-consuming rats exhibited mild to moderate physical dependence.

    Conclusions:

    • Schedule-induced polydipsia is a viable method for assessing midazolam's addiction liability.
    • Midazolam demonstrates potential for abuse and physical dependence.