Supramolecular cyclodextrin complex: Diversity, safety, and applications in ocular therapeutics

Area of Science:

• Pharmaceutical Sciences
• Ocular Drug Delivery
• Drug Formulation

Background:

• Many existing and new chemical entities (30-70%) suffer from poor aqueous solubility.
• Effective topical ocular drug delivery requires molecules with both hydrophilic and lipophilic properties for tear film absorption and corneal penetration.
• Techniques like cyclodextrin complexation are explored to enhance solubility and bioavailability.

Purpose of the Study:

• To review efforts addressing concerns associated with cyclodextrin use in ocular therapeutics.
• To discuss the utility of cyclodextrin systems in advanced ocular formulations.
• To summarize research on cyclodextrin's absorption enhancement, ocular surface retention, and safety profiles.

Main Methods:

• Literature review of research on cyclodextrin applications in ocular drug delivery.
• Analysis of studies addressing cyclodextrin's absorption enhancement mechanisms and ocular surface interactions.
• Examination of safety and toxicity profiles of cyclodextrins in ophthalmic preparations.

Main Results:

• Cyclodextrin inclusion complexation is a viable strategy for improving drug solubility and ocular delivery.
• Research is actively investigating and mitigating concerns regarding cyclodextrin's ocular absorption enhancement, retention, and potential for irritation.
• Cyclodextrins show promise in novel ocular delivery systems like contact lenses, inserts, and implants.

Conclusions:

• Cyclodextrins offer significant potential for overcoming solubility challenges in ocular drug delivery.
• Further research and formulation development are crucial to optimize cyclodextrin-based ocular therapies and ensure their safety and efficacy.
• Cyclodextrin systems are valuable for developing advanced ocular drug delivery platforms, including contact lenses and implants.