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[Asthma: endotypes and phenotypes at a pediatric age].
1Hospital Clinic-Sant Joan de Deu, Servicio de Inmunología y Alergia Pediátrica, Barcelona, España. 5314fml@comb.cat.
Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993)
|October 14, 2019
Summary
Asthma endotypes and phenotypes are identified by genetic, environmental, and non-inherited factors. Allergens like Dermatophagoides mites are common triggers, influencing asthma onset and characteristics across different patient groups.
Area of Science:
- Pediatric Allergy and Immunology
- Respiratory Medicine
- Epigenetics
Background:
- Asthma presents with diverse clinical manifestations and underlying biological mechanisms.
- Understanding asthma variants requires considering genetic, environmental, and epigenetic interactions.
- Allergens play a significant role in asthma development, particularly in children and adolescents.
Purpose of the Study:
- To explore the concepts of endotype and phenotype in pediatric and adult asthma.
- To investigate the interplay of genetic, environmental, and non-inherited factors in asthma.
- To analyze differences in asthma onset and characteristics based on family history and IgE levels.
Main Methods:
- Review of 100 medical records of children with and without a family history of asthma.
- Analysis of a patient group with normal IgE levels.
- Comparison of allergen sensitization patterns, specifically to Dermatophagoides mites.
Main Results:
- Identified distinct differences in age of onset and other characteristics among the studied groups.
- Observed similar sensitization to Dermatophagoides mites across groups, irrespective of family history or IgE levels.
- Highlighted the role of environmental factors in late-onset asthma, such as occupational asthma.
Conclusions:
- Endotype and phenotype concepts aid in classifying asthma variants.
- Environmental allergens are key contributors to asthma, especially in younger populations.
- Further research is needed to fully elucidate the complex factors influencing asthma heterogeneity.
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