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Updated: Jan 5, 2026
Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
Published on: February 28, 2025
Bioinspired multifunctional biomaterials with hierarchical microstructure for wound dressing.
Jianmin Xue1, Xiaocheng Wang1, Endian Wang1
1State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, No.1295 Dingxi Road, Shanghai 200050, People's Republic of China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, No. 19(A) Yuquan Road, Beijing 100049, People's Republic of China.
Researchers developed a nacre-inspired biomaterial from graphene oxide, chitosan, and calcium silicate. This hierarchical material offers enhanced strength, breathability, and water absorption for advanced wound healing applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Bioinspired Engineering
Background:
- Developing wound dressings with mechanical strength and multifunctionality is crucial for skin wound treatment.
- Nacre's hierarchical structure inspires high-performance biomaterials, but its application in tissue engineering requires further investigation.
Purpose of the Study:
- To fabricate a nacre-inspired hierarchical graphene oxide-chitosan-calcium silicate (GO-CTS-CS) biomaterial.
- To evaluate its mechanical properties, biocompatibility, and therapeutic potential for wound healing.
Main Methods:
- Fabrication using vacuum filtration-assisted assembly and freeze-drying.
- Characterization of hierarchical microstructure (lamellar and "brick-and-mortar" structures).
- Assessment of mechanical strength, breathability, water absorption, photothermal performance, and in vivo wound healing efficacy.
Main Results:
- The GO-CTS-CS biomaterial exhibited a bioinspired hierarchical microstructure.
- Achieved excellent tensile strength, compatible breathability, and water absorption.
- Demonstrated significant photothermal antibacterial and antitumor effects.
- Showed a stimulatory effect on in vivo chronic wound healing.
Conclusions:
- The nacre-inspired hierarchical GO-CTS-CS biomaterial possesses desirable mechanical and functional properties for wound dressings.
- Its multifunctional capabilities, including photothermal therapy and wound healing promotion, offer a promising alternative to traditional treatments.
- Constructing hierarchical microstructures in biomaterials is vital for advancing tissue engineering and regenerative medicine.
