Related Experiment Video
Updated: Jan 5, 2026
Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
Published on: March 25, 2019
High accuracy detection of malignant pleural effusion based on label-free surface-enhanced Raman spectroscopy and
Kaiyuan Liu1, Shangzhong Jin1, Zhengbo Song2
1Department of Optical and Electronic Technology, China Jiliang University, Hangzhou, 310018, China.
Abstract:
The present study aims to diagnose malignant pleural effusion (MPE) based on the identification of distinctive Raman spectra bands. The tests on 83 pleural effusion (PE) samples including 32 benign PE (BPE) and 51 MPE were performed based on rapid and label-free surface-enhanced Raman spectroscopy (SERS). The TiO2 photo-catalyzed Ag NPs were used as SERS substrate. And the SERS spectra of BPE and MPE were compared and diagnosed through orthogonal partial least squares discriminant analysis (OPLS-DA). The diagnosis results showed that the sensitivity and specificity can reach 92.2% and 93.8%, respectively, based on leave-one-out cross validation. And the area under curve values of MPE was 0.985. This study demonstrated an accurate way of combining Raman spectra of PE with OPLS-DA to identify MPE and BPE.
