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Updated: Jan 5, 2026

An HS-MRM Assay for the Quantification of Host-cell Proteins in Protein Biopharmaceuticals by Liquid Chromatography Ion Mobility QTOF Mass Spectrometry
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An HS-MRM Assay for the Quantification of Host-cell Proteins in Protein Biopharmaceuticals by Liquid Chromatography Ion Mobility QTOF Mass Spectrometry

Published on: April 17, 2018

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Direct measurement of light and heavy antibody chains using ion mobility and middle-down mass spectrometry

Rafael D Melani1, Kristina Srzentić2, Vincent R Gerbasi1

  • 1Departments of Chemistry, Molecular Biosciences, and Chemical and Biological Engineering; the Chemistry of Life Processes Institute; and the Proteomics Center of Excellence, Northwestern University , Evanston , IL , USA.

Mabs
|October 15, 2019
PubMed

Keywords:
FAIMSgas-phase fractionationlight and heavy chainsmAbmiddle-down analysis

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