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Exercise and Parkinson's disease.

Xiaojiao Xu1, Zhenfa Fu1, Weidong Le1

  • 1Center for Clinical Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, China; Liaoning Provincial Key Laboratory for Research on the Pathogenic Mechanisms of Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, China.

International Review of Neurobiology
|October 15, 2019
PubMed
Summary

Regular exercise offers significant benefits for Parkinson's disease (PD) patients. It improves motor and non-motor symptoms, reduces medication side effects, and supports brain health, making it a valuable complementary therapy.

Keywords:
Brain healthDrug interactionExerciseNeurotrophic factorParkinson's diseaseRehabilitation

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Area of Science:

  • Neuroscience
  • Gerontology
  • Exercise Science

Background:

  • Parkinson's disease (PD) is a prevalent neurodegenerative disorder with limited disease-modifying treatments.
  • Current therapies primarily manage symptoms, lacking the ability to halt disease progression.
  • Growing evidence suggests exercise interventions positively impact PD.

Purpose of the Study:

  • To review the beneficial effects of exercise on Parkinson's disease.
  • To elucidate the underlying mechanisms through which exercise impacts PD.
  • To highlight exercise as a promising complementary therapy for PD.

Main Methods:

  • Review of recent research on exercise and Parkinson's disease.
  • Analysis of studies investigating exercise's effects on motor and non-motor symptoms.
  • Examination of research on exercise's impact on neuroplasticity and cellular mechanisms.

Main Results:

  • Exercise demonstrates positive effects on both motor and non-motor symptoms of PD.
  • Exercise can mitigate side effects of anti-PD medications, such as wearing-off and dyskinesia.
  • Exercise promotes brain maintenance and plasticity via neurogenesis, synaptogenesis, metabolism, and angiogenesis.

Conclusions:

  • Exercise positively influences PD by inhibiting oxidative stress, repairing mitochondrial damage, and boosting growth factors.
  • Exercise may reduce the risk and impact of comorbidities like diabetes and hypertension, which are linked to PD.
  • Exercise is a valuable complementary strategy to traditional PD medications, offering therapeutic potential.