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Related Experiment Video

Updated: Jan 5, 2026

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
05:51

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Enteroviral infection in neonates.

Yu-Yu Chuang1, Yhu-Chering Huang2

  • 1Department of Pediatrics, St. Mary's Hospital, Luodong, Yilan, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|October 15, 2019
PubMed
Summary

Enterovirus infections in newborns can be severe, mimicking bacterial sepsis. Early diagnosis and treatment, including intravenous immunoglobulin, are crucial for reducing infant morbidity and mortality.

Keywords:
CoagulopathyEnterovirusIntravenous immunoglobulinMyocarditisNeonates

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Area of Science:

  • Neonatal Medicine
  • Virology
  • Infectious Diseases

Background:

  • Enteroviruses typically cause mild illness but severe disease in neonates.
  • Neonatal enterovirus infections present symptoms similar to bacterial sepsis, complicating diagnosis.
  • Severe complications like hepatic necrosis, meningoencephalitis, and myocarditis are common in affected newborns.

Purpose of the Study:

  • To provide a comprehensive overview of non-polio enterovirus infections in neonates.
  • To discuss epidemiology, transmission, clinical presentation, diagnosis, and treatment strategies.
  • To emphasize the importance of considering enteroviruses in the differential diagnosis of neonatal sepsis.

Main Methods:

  • Literature review of enterovirus infections in neonates.
  • Analysis of clinical manifestations, risk factors, and outcomes.
  • Discussion of diagnostic tools like reverse-transcriptase polymerase chain reaction (RT-PCR).

Main Results:

  • Echoviruses and coxsackievirus B are the most common serotypes causing neonatal sepsis.
  • Severity is influenced by virus serotype, transmission, and maternal antibodies.
  • Rapid diagnostics and prompt treatment, including IVIG, can improve outcomes.

Conclusions:

  • Enterovirus infections are a significant cause of neonatal illness and require prompt recognition.
  • Awareness of clinical syndromes and risk factors aids timely diagnosis.
  • Aggressive management, including early IVIG, is vital for reducing severe outcomes in neonates.