Etchable SERS nanosensor for accurate pH and hydrogen peroxide sensing in living cells
Lu Bai1, Xiaojie Wang2, Kaifu Zhang1
1Key Laboratory of Advanced Energy Materials Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
Chemical Communications (Cambridge, England)
|October 15, 2019
Abstract:
No methodology has been built to distinguish intracellular SERS nanosensors from cell outer membrane bound-ones. Here we propose a "turning off" strategy by combining etchable SERS nanosensors with a non-permeable etchant. The SERS signals outside the living cells can be rapidly removed, leaving only the internalized nanosensors for imaging and thereby allowing accurate intracellular pH and H2O2 sensing.
