Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is the Immune System?01:38

What is the Immune System?

126.0K
Overview
126.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proteome-Wide Serological Profiling Reveals Broad Elevation of EBV Immunity in Idiopathic Pulmonary Fibrosis.

International journal of molecular sciences·2026
Same author

Differential antibody response to EBV proteome following EBVST immunotherapy in EBV-associated lymphomas.

Blood advances·2025
Same author

Differential EBV protein-specific antibody response between responders and non-responders to EBVSTs immunotherapy.

bioRxiv : the preprint server for biology·2024
Same author

A proteome-wide analysis unveils a core Epstein-Barr virus antibody signature of classic Hodgkin lymphoma across ethnically diverse populations.

International journal of cancer·2024
Same author

Comparative Analysis of the Humoral Immune Response to the EBV Proteome across EBV-Related Malignancies.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology·2023
Same author

The Effect of Tropical Temperatures on the Quality of RNA Extracted from Stabilized Whole-Blood Samples.

International journal of molecular sciences·2022
Same journal

Diversity, Equality, and Inclusion in the naïve T Cell Receptor Repertoire.

Immunological reviews·2026
Same journal

Macrophage Plasticity and Immune Remodeling in Ischemic Heart Failure.

Immunological reviews·2026
Same journal

The T Cell Receptor: Molecular Sensor, Therapeutic Mediator and Probabilistic Driver of Adaptive Immunity.

Immunological reviews·2026
Same journal

Tissue-Resident Memory T Cells in the Heart: An Emerging Role in Chronic Inflammation.

Immunological reviews·2026
Same journal

Rethinking Immunity in Tissues: The Biology of Tertiary Lymphoid Structures.

Immunological reviews·2026
Same journal

Inflammation-Driven Lymphoid Structures: Organization, Function, and Clinical Impact Across Autoimmunity, Cancer, and Checkpoint Toxicity.

Immunological reviews·2026
See all related articles

Related Experiment Video

Updated: Jan 5, 2026

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
08:46

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

18.1K

Deciphering host immunity to malaria using systems immunology.

Claire Loiseau1, Martha M Cooper1, Denise L Doolan1

  • 1Centre for Molecular Therapeutics, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Qld, Australia.

Immunological Reviews
|October 15, 2019
PubMed
Summary
This summary is machine-generated.

Systems immunology offers a holistic approach to understanding complex host-pathogen interactions, crucial for developing effective interventions against diseases like malaria. This strategy integrates immunology with computational sciences and omics technologies for better global public health outcomes.

Keywords:
Plasmodiumcontrolled infectionexperimental infectionimmunitymalarianaturally acquired immunityomicssystems immunology

More Related Videos

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection
08:14

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection

Published on: October 6, 2015

10.6K
High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
10:38

High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays

Published on: July 17, 2014

23.6K

Related Experiment Videos

Last Updated: Jan 5, 2026

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites
08:46

Myeloid Cell Isolation from Mouse Skin and Draining Lymph Node Following Intradermal Immunization with Live Attenuated Plasmodium Sporozoites

Published on: May 18, 2016

18.1K
An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection
08:14

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection

Published on: October 6, 2015

10.6K
High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays
10:38

High Yield Purification of Plasmodium falciparum Merozoites For Use in Opsonizing Antibody Assays

Published on: July 17, 2014

23.6K

Area of Science:

  • Immunology
  • Computational Biology
  • Infectious Diseases

Background:

  • Despite advances in infectious disease research, effective interventions and understanding of host immunity against complex pathogens like malaria remain limited.
  • Traditional reductionist approaches (gene-by-gene) fail to capture the complexity of host-pathogen immune responses.
  • A paradigm shift towards a holistic, whole-organism view is necessary to understand dynamic immune interactions.

Purpose of the Study:

  • To describe the systems immunology toolkit for interrogating immune responses at a systems level.
  • To report on studies applying systems-level approaches to malaria infection.
  • To highlight the potential of systems immunology for developing novel interventions.

Main Methods:

  • Integration of immunology with omics technologies (genomics, proteomics, etc.).
  • Application of computational sciences for data analysis and network modeling.
  • Deployment of systems-level approaches in natural and controlled human malaria infection models.

Main Results:

  • Systems immunology provides a comprehensive toolkit to analyze complex immune responses.
  • Studies using systems-level approaches offer new insights into host-pathogen dynamics during malaria.
  • This approach facilitates a deeper understanding of immunity to intractable pathogens.

Conclusions:

  • Systems immunology represents a powerful paradigm for understanding host-pathogen interactions.
  • This approach is essential for the rational design and development of effective interventions against diseases like malaria.
  • The integration of diverse technologies holds significant potential for improving global public health.