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Drugs for Treatment of Constipation-Predominant IBS01:21

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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
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Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
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Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
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Chronic constipation: new insights, better outcomes?

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Constipation affects many adults, often presenting as straining rather than infrequent bowel movements. Proper diagnosis requires excluding rectal outlet dysfunction before considering prescription treatments.

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Area of Science:

  • Gastroenterology
  • Internal Medicine

Background:

  • Constipation is a prevalent symptom affecting 11-20% of adults annually.
  • Patient perception of constipation often centers on straining, differing from the physician's focus on defecation frequency.

Purpose of the Study:

  • To highlight the discrepancy between physician and patient definitions of constipation.
  • To emphasize the importance of excluding rectal outlet dysfunction in constipation management.
  • To guide physicians in assessing and optimizing patient self-treatment strategies.

Main Methods:

  • Review of common diagnostic criteria and patient-reported symptoms for constipation.
  • Emphasis on physical examination to identify rectal outlet dysfunction.
  • Assessment of previous self-management attempts and prescription medication strategies.

Main Results:

  • A significant portion of patients experiencing constipation report excessive straining.
  • Rectal outlet dysfunction is present in approximately 25% of idiopathic constipation cases.
  • Effective management requires a tailored approach beyond simple laxative use.

Conclusions:

  • Constipation diagnosis and management should consider both physician and patient perspectives.
  • Excluding rectal outlet dysfunction is crucial for appropriate treatment selection.
  • Physicians play a key role in optimizing constipation management by assessing prior treatments and strategically using available therapies.