Randomized-controlled trial of a modified Mediterranean dietary program for multiple sclerosis: A pilot study.

Area of Science:

• Dietary Interventions
• Neurology
• Clinical Trials

Background:

• High interest exists regarding diet's role in multiple sclerosis (MS).
• Limited evidence supports Mediterranean diets for MS.
• Feasibility of educational dietary interventions in MS is unknown.

Purpose of the Study:

• Assess clinical trial feasibility of an educational dietary intervention for MS.
• Explore effects of a modified Mediterranean diet on MS symptoms.

Main Methods:

• Randomized 36 women with MS to a 6-month modified Mediterranean diet or control.
• Diet emphasized fish, fruits, vegetables, whole grains; excluded meat, dairy, processed foods; limited salt.
• Intervention delivered through educational sessions; primary endpoints were enrollment, adherence, completion.

Main Results:

• Enrolled 36/30 participants within 9 months, exceeding targets.
• Reported adherence was 90.3%; study completion was 94.4%.
• Intervention group showed significant reductions in fatigue, MS impact, and disability scores.

Conclusions:

• Educational delivery of a modified Mediterranean diet is feasible in MS clinical trials with high adherence.
• The diet intervention significantly reduced fatigue, MS symptoms, and disability.
• Further research is warranted to confirm these findings.