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PhaSePro: the database of proteins driving liquid-liquid phase separation.
Bálint Mészáros1, Gábor Erdős1, Beáta Szabó2
1MTA-ELTE Momentum Bioinformatics Research Group, Department of Biochemistry, Eötvös Loránd University, Budapest H-1117, Hungary.
Nucleic Acids Research
|October 16, 2019
Summary
PhaSePro is a new database for liquid-liquid phase separation (LLPS) driver proteins. This resource aids research into cellular organization by providing curated, validated data on LLPS proteins and regions.
Area of Science:
- Cell Biology
- Biochemistry
- Bioinformatics
Background:
- Membraneless organelles (MOs) organize cellular processes via liquid-liquid phase separation (LLPS).
- LLPS is driven by multivalent weak interactions of proteins and macromolecules.
- Computational identification of LLPS drivers lags behind experimental findings, hindering research.
Purpose of the Study:
- To introduce PhaSePro, a comprehensive, manually curated database of experimentally validated LLPS driver proteins and regions.
- To address the lack of a dedicated LLPS database and facilitate research in this field.
- To improve data standardization using novel LLPS-specific controlled vocabularies.
Main Methods:
- Manual curation of experimentally validated LLPS driver proteins and regions.
- Development of an openly accessible database with a user-friendly interface.
- Introduction of LLPS-specific controlled vocabularies for data standardization.
Main Results:
- PhaSePro provides a centralized resource for LLPS driver information.
- The database includes experimentally validated proteins and protein regions.
- Novel LLPS-specific controlled vocabularies enhance data standardization.
Conclusions:
- PhaSePro is a valuable, openly accessible resource for the scientific community.
- The database has the potential to become a central hub for LLPS research.
- Standardized data in PhaSePro will advance understanding of LLPS mechanisms and biological relevance.
