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Related Experiment Videos

Injectable collagen: a six-year clinical investigation.

L S Cooperman, V Mackinnon, G Bechler

    Aesthetic Plastic Surgery
    |January 1, 1985
    PubMed
    Summary
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    Injectable bovine collagen effectively corrects skin contour deficiencies with a low adverse reaction rate of 1.3%. This safe and efficacious dermal filler is widely used globally for various cosmetic applications.

    Area of Science:

    • Dermatology
    • Biomaterials Science
    • Plastic Surgery

    Background:

    • Injectable bovine dermal collagen has been developed as a medical device.
    • It is a sterile formulation of purified type I collagen in saline with lidocaine.
    • This collagen filler is used for correcting cutaneous contour deficiencies.

    Purpose of the Study:

    • To evaluate the safety and efficacy of injectable bovine collagen.
    • To assess adverse treatment reactions in patients receiving the collagen filler.
    • To determine the long-term effectiveness of collagen injections for dermal contour elevation.

    Main Methods:

    • A 6 1/2-year investigation involving 5,109 patients.
    • Data collected from 728 dermatologists and plastic surgeons.

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  • Analysis of adverse reactions and subjective efficacy assessments.

    • Main Results:

    • An overall adverse treatment reaction incidence of 1.3% was observed.
    • Most reactions were localized swelling and erythema.
    • Data from an estimated 100,000 patients showed no increase in reaction rates post-FDA clearance.
    • Subjective assessments indicated successful elevation of dermal contour defects.

    Conclusions:

    • Injectable bovine collagen is a safe and effective option for correcting dermal contour deficiencies.
    • The material demonstrates a low incidence of adverse reactions.
    • It is suitable for addressing defects from various etiological factors.